 Reference Base  Experimental Mycobacterium bovis infection in three white... |
|
Michel, A.L.; Lane, E.P.; Klerk-Lorist, L.M.de; Hofmeyr, M.; Heijden, E.M.D.L. van der; Botha, L.; Helden, P.van; Miller, M.; Buss, P., 2017. Experimental Mycobacterium bovis infection in three white rhinoceroses (Ceratotherium simum): Susceptibility, clinical and anatomical pathology. PLoS ONE 12(7): e0179943. https://doi.org/10.1371/journal.pone.0179943
|
|
|
|
| |
| Location: |
Africa - Southern Africa - South Africa |
| Subject: |
Diseases |
| Species: |
White Rhino |
 |
|
|
Tuberculosis caused by Mycobacterium bovis is endemic in the African buffalo (Syncerus caffer) population in the Kruger National Park and other conservation areas in South Africa. The disease has been diagnosed in a total of 21 free ranging or semi-free ranging wildlife species in the country with highly variable presentations in terms of clinical signs as well as severity and distribution of tuberculous lesions. Most species are spillover or dead-end hosts without significant role in the epidemiology of the disease. White rhinoceroses (Ceratotherium simum) are translocated from the Kruger National Park in substantial numbers every year and a clear understanding of their risk to manifest overt tuberculosis disease and to serve as source of infection to other species is required. We report the findings of experimental infection of three white rhinoceroses with a moderately low dose of a virulent field isolate of Mycobacterium bovis. None of the animals developed clinical signs or disseminated disease. The susceptibility of the white rhinoceros to bovine tuberculosis was confirmed by successful experimental infection based on the ante mortem isolation of M. bovis from the respiratory tract of one rhinoceros, the presence of acid-fast organisms and necrotizing granulomatous lesions in the tracheobronchial lymph nodes and the detection of M. bovis genetic material by PCR in the lungs of two animals
|
|
|
File available
details
Original text on this topic: